The MCCIR aims, with assistance from our industrial partners, to be at the cutting edge of basic and translational research into inflammatory diseases.
The Centre aims to be unique as it will perform pathway identification in man, validate these in pre-clinical models and then return with a therapeutic to man.
In the past analysis of pathways relevant to inflammation in pre-clinical models has reduced the complexity caused by the influence of genetic and environmental variability, allowing scientists to determine mechanism, cause vs effect precisely. However the relevance and efficacy to man of any therapies developed from this approach are determined. Similarly pathway analysis in man, though more relevant, cannot distinguish between cause and effect. Using the Centre’s unique approach to pathway identification we hope to overcome these main obstacles to the generation of new therapeutic angles in the treatment of inflammatory conditions.